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1.
An Otorrinolaringol Ibero Am ; 33(3): 257-72, 2006.
Artigo em Espanhol | MEDLINE | ID: mdl-16881553

RESUMO

In this paper we carried out an immunohistochemical study of cyclin D1 (DCS6 ) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied cyclin D1 expression at this level. Furthermore we have analysed the value of cyclin D1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between cyclin D1 expression and other clinic and pathologic parameters.


Assuntos
Carcinoma de Células Escamosas/metabolismo , Ciclina D1/biossíntese , Neoplasias Laríngeas/metabolismo , Idoso , Humanos , Imuno-Histoquímica , Prognóstico
2.
An Otorrinolaringol Ibero Am ; 33(1): 41-56, 2006.
Artigo em Espanhol | MEDLINE | ID: mdl-16566195

RESUMO

In this paper we carried out an immunohistochemical study of protein p27KIP1 expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied p27KIP1 expression at this level. Furthermore we have analysed the value of protein p27KIP1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between p27KIP1 expression and other clinic and pathologic parameters.


Assuntos
Carcinoma de Células Escamosas/metabolismo , Inibidor de Quinase Dependente de Ciclina p27/metabolismo , Neoplasias Laríngeas/metabolismo , Idoso , Carcinoma de Células Escamosas/patologia , Humanos , Imuno-Histoquímica , Neoplasias Laríngeas/patologia , Estadiamento de Neoplasias , Fenótipo , Prognóstico
3.
An Otorrinolaringol Ibero Am ; 32(2): 159-73, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-15929589

RESUMO

In this paper we carried out an immunohistochemical study of protein Rb (G3-245) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied Rb expression at this level. Furthermore we have analysed the value of Rb expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between Rb expression and other clinic and pathologic parameters.


Assuntos
Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/patologia , Neoplasias Laríngeas/metabolismo , Neoplasias Laríngeas/patologia , Proteína do Retinoblastoma/biossíntese , Idoso , Seguimentos , Humanos , Imuno-Histoquímica , Prognóstico
4.
An Otorrinolaringol Ibero Am ; 32(1): 7-22, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-15803916

RESUMO

In this paper we carried out an immunohistochemical study of protein p21WAF1 (EA10) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied p21WAF1 expression at this level. Furthermore we have analysed the value of protein p21WAF1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between p21WAF1 expression and other clinic and pathologic parameters.


Assuntos
Carcinoma de Células Escamosas/metabolismo , Proteínas de Ciclo Celular/metabolismo , Neoplasias Laríngeas/metabolismo , Idoso , Carcinoma de Células Escamosas/patologia , Inibidor de Quinase Dependente de Ciclina p21 , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Laríngeas/patologia , Masculino , Estadiamento de Neoplasias , Prognóstico , Proteína Supressora de Tumor p53/metabolismo
5.
An Otorrinolaringol Ibero Am ; 32(1): 29-46, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-15803918

RESUMO

In this paper we carried out an immunohistochemical study of bcl-2 protein expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain). In the cases with lymphonode metastasis we also analysed bcl-2 protein expression at this level. Furthermore we have studied the value of bcl-2 protein expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we analysed the relationship between bcl-2 protein expression and other clinic and pathologic parameters.


Assuntos
Carcinoma de Células Escamosas/metabolismo , Neoplasias Laríngeas/metabolismo , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Proteína Supressora de Tumor p53/imunologia , Proteína Supressora de Tumor p53/metabolismo , Idoso , Anticorpos Monoclonais/imunologia , Carcinoma de Células Escamosas/imunologia , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Laríngeas/imunologia , Masculino , Estadiamento de Neoplasias , Prognóstico , Proteínas Proto-Oncogênicas c-bcl-2/imunologia
6.
An Otorrinolaringol Ibero Am ; 31(6): 515-29, 2004.
Artigo em Espanhol | MEDLINE | ID: mdl-15663083

RESUMO

We carried out an immunohistochemical study of p53 (DO7) expression in a series of 195 patients with laryngeal squamous cell carcinoma, treated and followed at the Department of Otolaryngology Virgen de la Salud Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied p53 expression at this site. We have investigated the value of p53 expression as a prognostic factor (tumor recurrence, deads due tu cancer and survival) and we have evaluated the relationship between p53 expression and other clinicopathologic characteristics.


Assuntos
Neoplasias Laríngeas/genética , Neoplasias Laríngeas/imunologia , Proteína Supressora de Tumor p53/genética , Proteína Supressora de Tumor p53/imunologia , Idoso , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Laríngeas/patologia , Masculino , Invasividade Neoplásica , Estadiamento de Neoplasias , Prognóstico
7.
An Otorrinolaringol Ibero Am ; 31(6): 571-82, 2004.
Artigo em Espanhol | MEDLINE | ID: mdl-15663089

RESUMO

In this paper we carried out an immunohistochemical study of Mdm-2 (IF2) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at Virgen de la Salud Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied Mdm-2 expression at this level. We also wanted to investigate the value of Mdm-2 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we have evaluated the relationship between Mdm-2 expression and other clinic and pathologic characteristics.


Assuntos
Carcinoma de Células Escamosas/genética , Neoplasias Laríngeas/genética , Proteínas Nucleares/genética , Proteínas Proto-Oncogênicas/genética , Idoso , Carcinoma de Células Escamosas/mortalidade , Cromossomos Humanos Par 12/genética , Intervalo Livre de Doença , Humanos , Imuno-Histoquímica , Neoplasias Laríngeas/mortalidade , Estadiamento de Neoplasias , Fenótipo , Prognóstico , Proteínas Proto-Oncogênicas c-mdm2
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